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Posts Tagged ‘brain implants’

The team’s synthetic cerebellum is more or less a simple microchip, but can receive sensory input from the brainstem, interpret that nerve input, and send the appropriate signal to a different region of the brainstem to initiate the appropriate movement. Right now it is only capable of dealing with the most basic stimuli/response sequence, but the very fact that researchers can do such a thing marks a pretty remarkable leap forward.

To achieve such a breakthrough, the cerebellum was a pretty ideal place to start. Its architecture is simple enough and one of its functions is to orchestrate motor movements in response to stimuli, making it easy enough to test. Using what they already knew about the way a rat’s cerebellum interacts with its brainstem to generate motion, they built a chip that mimicked that kind of neural processing and activity.

They then hooked up their chip to a rat whose cerebellum had been disabled (they did this externally, with the chip connected to the brain by electrodes--they did not implant the chip in the rat’s brain). Before hooking up their synthetic chip, they tried to teach the rat a behavior with its cerebellum switched off by combining an auditory tone with a puff of air to the rat’s eye that caused it to blink. The rat should’ve quickly learned to blink its eye at the stimulus of the tone alone without the puff of air (think Pavlov), but with its cerebellum disabled it could not.

The team then switched on the synthetic cerebellum chip. Soon enough, the rat learned to blink at the sound of the tone as a normal rat would. Their chip proved a sufficient stand-in for the rat’s own neural tissue.

This is a simple stimulus-response, but it’s also huge in terms of what it means for our understanding of how to manipulate the brain. The system would clearly have to be scaled way up for human use, which is not expected any time in the foreseeable future. But it does swing the door wide open for future synthetic implants that could replace nervous tissue damaged by injury, stroke, or age-related degradation.

Mash that up with the huge leaps being made all the time in robotic prosthetics and brain-computer interfaces, and you’re quickly wandering into full-on cyborg territory. See, we told you the future is now.

[New Scientist]

Doctors at Glasgow's Southern General Hospital will conduct periodic MRI scans to look for repairs or changes in areas of the patient’s brain damaged by stroke. The trial, called Pilot Investigation of Stem Cells in Stroke (PISCES), is designed to check the procedure’s safety, but any signs of physical improvement would be a major leap in neural medicine.

Before the surgery, researchers at UK company ReNeuron grew the stem cells into neural stem cells. British media said the company obtained the cells from a donated 12-week-old human fetus from the U.S. (An embryo becomes a fetus about eight weeks after fertilization.)

The procedure was initially approved last year.

Keith Muir of the University of Glasgow, the lead researcher on the trial, said some of the injected neural stem cells would grow into neurons. But they could prove even more versatile — earlier studies in rats showed that the stem cells triggered a wide variety of cell development, including new brain blood vessels.

During the next year, as many as 12 other patients will get progressively higher doses of stem cell injections, reaching as many as 20 million cells, according to Muir.

Stem cells are valuable because they can become any type of cell in the body, but are controversial because embryonic stem cells require the destruction of human embryos. The National Institutes of Health is embroiled in a legal wrangle over whether its federally funded researchers can study human embryonic stem cells; for now, research is progressing, but the future is in the hands of the courts.

Doctors in Russia, China and other nations offer stem cell therapy to patients with a host of maladies, but the treatments are often poorly regulated or not at all.

Despite the controversies, the Scottish trial is the second notable embryonic stem cell implantation procedure in as many months. After years of delays, the first American embryonic stem cell therapy for spinal injuries started last month, when a spinal patient received a stem cell injection into the spinal cord. Again, the study’s goal is to prove the treatment is safe, but doctors hope the paralyzed patient will see some physical improvement. As many as nine other patients may join that study.

In August, an Iraq war veteran became the first recipient of an adult stem cell implant, also to treat a spinal injury.

The implants would use light pulses to activate certain brain regions and reroute function

Such brain implants made from electrodes or optical fibers would sit on the brain's surface and monitor the electrical signals sent among neurons. They would also beam light pulses to stimulate specific parts of the brain in response, and ideally help the brain function normally despite having damaged areas.

The appropriately-named REPAIR (Reorganization and Plasticity to Accelerate Injury Recovery) project involves a team led by Stanford and Brown universities working with a two-year budget of $14.9 million. First up for the optogenetic tests are mice, rats and eventually monkeys.

Learning how to manage the human brain has been a top priority for DARPA in recent years, given the mad science lab's orders for technology such as cryogenic methods to freeze traumatic brain injury in its tracks. But they also seek to co-opt the brain's power for directly controlling prosthetic limbs usable by wounded warfighters. Even if this latest venture does not directly heal, it may at least help negate the effects of brain injuries so that it's as if they never existed.

[via Wired's Danger Room]

The implants would use light pulses to activate certain brain regions and reroute function

Such brain implants made from electrodes or optical fibers would sit on the brain's surface and monitor the electrical signals sent among neurons. They would also beam light pulses to stimulate specific parts of the brain in response, and ideally help the brain function normally despite having damaged areas.

The appropriately-named REPAIR (Reorganization and Plasticity to Accelerate Injury Recovery) project involves a team led by Stanford and Brown universities working with a two-year budget of $14.9 million. First up for the optogenetic tests are mice, rats and eventually monkeys.

Learning how to manage the human brain has been a top priority for DARPA in recent years, given the mad science lab's orders for technology such as cryogenic methods to freeze traumatic brain injury in its tracks. But they also seek to co-opt the brain's power for directly controlling prosthetic limbs usable by wounded warfighters. Even if this latest venture does not directly heal, it may at least help negate the effects of brain injuries so that it's as if they never existed.

[via Wired's Danger Room]

The implants would use light pulses to activate certain brain regions and reroute function

Such brain implants made from electrodes or optical fibers would sit on the brain's surface and monitor the electrical signals sent among neurons. They would also beam light pulses to stimulate specific parts of the brain in response, and ideally help the brain function normally despite having damaged areas.

The appropriately-named REPAIR (Reorganization and Plasticity to Accelerate Injury Recovery) project involves a team led by Stanford and Brown universities working with a two-year budget of $14.9 million. First up for the optogenetic tests are mice, rats and eventually monkeys.

Learning how to manage the human brain has been a top priority for DARPA in recent years, given the mad science lab's orders for technology such as cryogenic methods to freeze traumatic brain injury in its tracks. But they also seek to co-opt the brain's power for directly controlling prosthetic limbs usable by wounded warfighters. Even if this latest venture does not directly heal, it may at least help negate the effects of brain injuries so that it's as if they never existed.

[via Wired's Danger Room]

The implants would use light pulses to activate certain brain regions and reroute function

Such brain implants made from electrodes or optical fibers would sit on the brain's surface and monitor the electrical signals sent among neurons. They would also beam light pulses to stimulate specific parts of the brain in response, and ideally help the brain function normally despite having damaged areas.

The appropriately-named REPAIR (Reorganization and Plasticity to Accelerate Injury Recovery) project involves a team led by Stanford and Brown universities working with a two-year budget of $14.9 million. First up for the optogenetic tests are mice, rats and eventually monkeys.

Learning how to manage the human brain has been a top priority for DARPA in recent years, given the mad science lab's orders for technology such as cryogenic methods to freeze traumatic brain injury in its tracks. But they also seek to co-opt the brain's power for directly controlling prosthetic limbs usable by wounded warfighters. Even if this latest venture does not directly heal, it may at least help negate the effects of brain injuries so that it's as if they never existed.

[via Wired's Danger Room]

The implants would use light pulses to activate certain brain regions and reroute function

Such brain implants made from electrodes or optical fibers would sit on the brain's surface and monitor the electrical signals sent among neurons. They would also beam light pulses to stimulate specific parts of the brain in response, and ideally help the brain function normally despite having damaged areas.

The appropriately-named REPAIR (Reorganization and Plasticity to Accelerate Injury Recovery) project involves a team led by Stanford and Brown universities working with a two-year budget of $14.9 million. First up for the optogenetic tests are mice, rats and eventually monkeys.

Learning how to manage the human brain has been a top priority for DARPA in recent years, given the mad science lab's orders for technology such as cryogenic methods to freeze traumatic brain injury in its tracks. But they also seek to co-opt the brain's power for directly controlling prosthetic limbs usable by wounded warfighters. Even if this latest venture does not directly heal, it may at least help negate the effects of brain injuries so that it's as if they never existed.

[via Wired's Danger Room]